ISSN 1662-4009 (online)

ey0015.8-20 | Reviews | ESPEYB15

8.20 Hypothalamic-pituitary-adrenal (HPA) axis suppression after treatment with glucocorticoid therapy for childhood acute lymphoblastic leukaemia

N1 Rensen , RJ Gemke , EC van Dalen , J Rotteveel , GJ Kaspers

To read the full abstract: Cochrane Database Syst Rev. 2017; 11:CD008727Glucocorticoids (GCs), such as prednisone (prednisolone) or dexamethasone, are essential agents in the treatment of acute lymphoblastic leukemia (ALL), the most common malignancy in childhood. They are administered in highly supraphysiologic doses in cyclic courses. Thus, every pediatric endocrinologist fears HPA axi...